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Conclusion The most defensible interpretation of the published literature is that AOD9604 produced measurable lipid-metabolism-related effects in several defined obese-rodent models and showed a complex association with beta-3-adrenergic-receptor biology

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Transduced DG-75 cells (2 10 6 ) in 0.1 ml of phosphate buffer saline (PBS) were injected subcutaneously in the dorsal flanks of 8-to 10-week-old female NOD.CB17-Prkdcscid/J mice (Charles River Laboratories, Wilmington, MA, USA)

Patients are encouraged to consult with their healthcare provider if symptoms persist or worsen